Pharmacokinetic Study of Dermal Exposure to PFAS

Project Title: Pharmacokinetic Study of Dermal Exposure to PFAS Present in Firefighter Turnout Gear

This project addresses firefighter dermal exposure to per- and polyfluoroalkyl substances (PFAS), with a particular focus on short-chain, volatile compounds that has the potential to penetrate the skin. It aims to study the pharmacokinetics meaning the absorption, distribution, metabolism, and excretion (ADME) of PFAS following dermal exposure from firefighting gear. The project combines in vitro and in vivo approaches. Initially, flow-through diffusion tests are conducted on synthetic skin membranes to evaluate the permeability of PFAS compounds in a controlled conditions. In vivo studies use pig models to simulate realistic exposure conditions, including repeated dermal exposure over two-week periods. These in vivo tests are designed to provide comprehensive data on PFAS within a biological system, including deposition in blood, tissues, and organs. Additionally, the study investigates the potential biotransformation of PFAS into other metabolites within the body. The findings will provide a better understanding of occupational exposure of PFAS via dermal route.

• Grant: National Institute of Standards & Technology (Jan. 2024 – Dec. 2026)
• Award Amount: $419,891